The Pantera webstore
Click her to see an exhibition of quality cosmetics, daily skin care products, and serums, salves, pills against all common skin problems in kids and adults, including acne, rosacea, vitiligo, warts, stretchmarks.
Click here to see an exhibition of pills, creams, devices and toys for men and woman to improve sexual fitness amplify sexual satisfaction and enlarge the erections, penile size and breast size.
Click here for: Products to help for edema, hemorrhoids, constipation, rheumatism, cold and flu, UTI, candida, fatigue, poor sleep, prostata trouble, PMS, poor thyroid function, diabetes, ailments
Main meny with links to information about health, technology and science, and some smart products within each field
Anti-aging Products for Body, Hair, Skin and Mental capacities
Welcome to this online store with high class products for the care of your skin and your hair, with medicines to treat skin problems, and with high quality cosmetic items. Pleace click on the brand labels to learn more or order. Further down on this page you also will find some information about skin anatomy and the changing in the skin during aging
Anti-aging drugs with effect on the whole body
Products to henhance and rejuvenate mental abilities and the function of the nerve system
Topical products to rejuvenate the skin and also to treat red skin, inflamed skin, stretch marks, swallen skin and puffy eyes
Products for hair regain and rejuvenation
Some vitalizing products for the sexual life
General knowladge about skin anatomy, skin physiology and skin aging
Natural anti-aging drugs for the whole body
GenFx and Genf20Plus - pills to reverse aging for men and women - get smoother and firmer skin, better muscles intactness, stronger sexual life and stronger physiology - Human growth hormone has proved to help regain skin thickness, muscle intactness, a jouvenile muscle/fat-ratio and other properties of youth. These products stimulate your body to produce more growth hormone. In addition to a rejuventation of the skin and muscles, you can also expect more sensorial acuity, better allertness, better sex drive, have it easier to loose weight, have more energy, better management of blood sugar and have a better blood circulation. Please look at the products and choose that which suits best.
Please click here for a thorrough description or to buy - Genfx
Please click here for a thorrough description or to buy - Genf20plus
Provacyl - anti-aging pills for men - peak effects are rejuvenation of sexual functions, increased feeling of vitality and less body fat - This product is formulated especially for men that are over their middle ages or of other reasons have a declined production and controle of the hormons that are necessary to maintain a youthful sexual function, a youthful muscle intactness and a yourhful fat distribution. The most pronounced effects are increased sexual performance, reduction of body fat mass, more muscle mass and increased well-being.
Please click here for a thorrough description or to buy - Provacyl
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Natural anti-aging drugs for the brain and nervous system
To increase your allertness, thinking power and memory capacity - Brain Pills - These pills will enhance your allertness and acuity. They will boost your thinking capacity, problem solving speed and mental endurance. They will make you able to store much more information in your memory and use less time to store and retrieve the information. These pills are constructed and endorced by neurological experts and also recommended by several celebrities that depend heavily on their mental power. Among the working ingredients are Citicoline, Bacopa monnieri, Ginkgo biloba, phosphatidylcerine, tyrosine and L-theanine. The pills are ideal for every person with a mentally demanding work, for students and anyone that have got mentally exhausted by the impacts of daily life.
Please click here for a thorrough description or to buy - Brain pills
To help get better ability to focus on tasks, remember and learn - Listol - The impacts of daily life, often combined with lack of certain nutrients can cause reduced ability to focus on mental work and catch information in the memory. This product is formulated to improve the ability to focus, remember and learn. One key ingredient is the substance is GABA which is used as neurotransmitter in the brain. As this problem can affect young and old, people of any age with focusing problems may benefit from the product, including those with ADHD symptoms.
Click here to buy or learn more - Listol
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Anti-aging and general healing products for the skin
Instantwriclereduser - a serum for the skin to instantly reduce wrincles and give it a smooth young look - This topical serum contains a peptid that works in the same way as botox. It makes wrincling cramps in the fine muscles under the skin cease. The serum also helps the skin to ratain moisture better, which also takes away wricles. The full effect lasts around 8 hours.
Please click here to read more or buy Instantwrinklereducer
Argan Oil - a botanical oil with strong anti-aging effects for the skin, the hair and the nails - The oil decellerate aging of the skin, gives healing from fine lines and wrinckles, deeply remoisturizes the skin, induces repair of the colagen and elastin networks, helps repair sun damaged skin. The oil protects against free radicals, it Combatts acne, eczema, and psoriasis, it is fine to strengthen the nails with, and it helps to repairs frizzy and split hair. This product is a pure cold-pressed argan oil. Argan oil has a very long traditional use in Marocco and other north African countries as a general remedy to keep the skin young and healthy and to protect against harsh environmental impacts.
Please click here for a thorrough description or to buy - Skinceptionarganoil
Phyto350 - anti-aging pills for the skin - These pills contain antioxidant and regeneration-stimulating substances extracted from plants. They have a special profond effect in the skin, so that structure weakness due to aging are remended
Please click here for a thorrough description or to buy - Phyto350
Kollagen intensive - against wrinkles and skin aging - This is a clinically proven natural topical drug to fight back wrinkles and other aging changes in the skin. A main working principle of this remedy is to make the skin produce more collagen, the skin's most important structure protein and to better maintain the structure of the collagen framework.
Please click here for a thorrough description or to buy - collagenintensive
Treatment for red skin and dilated blood vessels in the skin - As one ages, many people experience that the vessels in their face and other places get widened, they look ruptured, the skin is also often inflamed and swallen and the face is generally red in an unpleasant way. The condition is also called rosacea. Here is presented a good product that helps against this type of skin aging.
A clinically proven serum to get rid of unpleasant redness and infalted red vessels in the skin - Rosacea Relief Serum
A good cream for treatment of stretch marks - This clinically proven cream can take away much of the stretch marks you have, up to 72,5% of the stretch mark amount is cured after use in two months, and the improvement continues by use of the product also after that time.
Please click here to read more or buy
Eyeelasticy - Serum to treat puffiness, bagging and aging signs around the eyes - like crow's feet, laugh lines, darkened skin and puffiness. The product works by boosting the production of structural factors necessary for a youthful skin structure an by making the skin using these factors to repair the damages. Please click here
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Anti-aging hair care products
Hair care set to help against thin hair and baldness - for men and women - Profollica - This is a total hair care package with effective substances to treat hair loss - containing a shampoo, a gel and herbal supplement. Loss or thin hair can also be a problem for women, and the product is suited as well for women as for men.
Please click here to learn more or buy - profollica
Increase your hair growth regain hair - for both sexes with Advecia - Advecia is a new all-natural herbal supplement with ingredients proven to provide hair follicles with essential nutrients that aid in strengthen the hair follicle and the production of hair from the follicles. It may slow down or stop hair loss and may rewake dormant follicles.
Please click here to learn more or buy - Advecia
Stopgrowthnow - topical hair remover for women and men - Removes unwanted hair by interrupting the initial phace of the growth of a new hair, thins out existing hair, reduces hair size. It decreases need for vaxing and shaving.
Please click here to learn more or buy
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Products tp vitalize sexual life
VigRXPlus - pills for men to enhance erection potency, increase erection size and boost good feelings - click here
Provestra - pills for women to stimulate lubrication, sexual functions, dezire and feelings, fine to regain the taste for sex by stressful periods - click here
VigRXoil- cream for men to give immediate hard stable erections and good feelings - click here
Vigorell - cream for women to stimulate functions in the genital region and tease up her most intimate sensations - click here
Even more roducts to improve and develop sexual life - please click here
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Some educational resources
Here you find articles about skin and skin aging. We also have other articles with in depth information. To see a list of these, please click here.
Generally about the skin and its functions
The skin is the largest organ of the body. As our major interface with the environment, the skin, composed of specialized epithelial and connective tissue cells, has many protective and synthetic functions.
FUNCTIONS OF THE SKIN
The skin acts as a barrier against such things as water loss/entry, chemicals, bacteria and fungic as well as against minor trauma.
This function is served by the lipids and proteins of the stratum corneum, the outermost epidermal layer, which is continually sloughed off and regenerated.
The stratum corneum varies in thickness: Thin on the upper arm, thick on the soles, palms, and areas of chronic friction.
Beneath the dermis is the subcutanous fat (hypodermis), a thermal barrier and mechanical cushion which varies in thickness from person to person and in various anatomic sites.
Elaborate neural receptors and small nerve endings mediate touch, position, pressure, temperature, and pain.
C. Thermoregulation via the eccrine sweat gland apparatus
D. Immunological defense via the Langerhans cells
E. Vitamin-D synthesis in response to sun exposure
F. Pigmentation/color for UV protection
G. Wound Healing
H. Reproductive function
ANATOMY OF THE SKIN
THE OUTER PART OF THE SKIN OR EPIDERMIS
LAYERS OF EPIDERMIS:
The epidermis forms the external surface of the skin and is mainly composed of keratinocytes which differentiate to form 4 layers, the Stratum Basale (basal layer), Stratum Spinosum (spinous or prickle cell layer), Stratum Granulosum (granular layer), and Stratum Corneum (surface layer).
a. Stratum Basale
The basal layer consists of 1 cell layer of cuboidal cells attached by hemi-desmosomes to a thin basement membrane which separates it from the underlying dermis. Mitotic figures are usually in this layer, and the cells are interconnected by desmosomes and gap junctions.
b. Stratum Spinosum
Above the basal layer is the spinous or prickle cell layer so named because of the prickly appearance at high magnification due to the fine cell processes containing desmosomes attaching one polyhedral-shaped cell to another. ( NOTE: If these desmosomes are damaged, as in the autoimmune disease pemphigus, the epidermal cells become separated, a process called acantholysis, and an intraepidermal blister results). Active protein synthesis occurs in this layer, producing a fibrillar protein keratin which aggregates to form tonofibrils. These tonofibrils migrate to the granular layer to eventually become part of the keratin complex (see Stratum Granulosum).
c. Stratum Granulosum
Above the spinous layer is the granular layer, in which each keratinocyte contains basophilic keratohyalin granules. The protein filaggrin is a major component of these granules, and it is thought to bind to the keratin filaments (a modified form of the tonofibrils produced in the spinous layer) to form the keratin complex. The cells also synthesize lipids which are believed to serve as "intercellular cement".
d. Stratum Corneum
The outer layer of the epidermis is the corneal layer which consists of fully keratinized, flat, fused cells bound together by lipids synthesized in the granular layer. The protein involucrin is produced in the stratum granulosum and corneum and forms a thickened protein layer on the inner surface of the plasma membrane.
CELLS FOUND IN THE EPIDERMIS:
The Basal keratinocyte is a mitotically active cell (analogous to the stem cell of bone marrow), which differentiates terminally from the basal (least keratin) to the cornified cells (most keratin). As it migrates upward, there is progressive synthesis of keratin proteins, which constitute part of the protective interface between the body and the environment. The migration process normally takes approximately 28 days (NOTE: This cell turnover process is abnormally rapid in psoriasis).
b. Melanocytes (pigment cells):
Produce melanin for skin pigmentation, which is partially protective against UV radiation. These cells are derived from the neural crest and migrate to the basal layer of the epidermis during fetal development, where they become interspersed among the keratinocytes by 8-10 weeks of gestation in the cephalic skin and by the 4th month of gestation in the caudal regions. Melanosomes (pigment containing granules produced within melanocytes) are present in melanocyte dendrites and are transferred to surrounding keratinocytes.
The melanocytes tend to form a cap over the keratinocyte nucleus and partially protect it from UV radiation. Melanin synthesis is controlled by melanocyte-stimulating hormone (MSH) from the pituitary gland. (NOTE: Some pigment cells fail to remain in their basal destination, instead re-entering the dermis as nests of pigment cells (*gross photo). These nests form the melanocytic nevi which may be acquired during postnatal life or may be congenital. Some uncommon melanocytic nevi arise by failure of migration into the epidermis. Nevi will be discussed in the section titled "Disorders of Melanocytes").
c. Langerhans' cells:
These are dendritic antigen-presenting cells intimately involved in immunological responses in the skin.
d. Merkel cells:
Merkel cells are neuroendocrine cells which form a small percentage of the cells in the basal layer. They have contact with small unmyelinated nerve endings and may function as a slow mechanoreceptor.
THE MID PART OF THE SKIN OR DERMIS
LAYERS OF THE DERMIS:
The dermis is separated from the epidermis by the basement membrane and this junction consists of the interlocking rete ridges and dermal papillae. The dermis is divided into 2 layers, the papillary dermis and the reticular dermis.
CELLULAR COMPONENTS OF THE DERMIS:
Fibroblasts(synthesize collagen, elastin, and reticulin), histiocytes, endothelial cells, perivascular macrophages and dendritic cells, mast cells, smooth musce, and cells of peripheral nerves and their end-organ receptors.
STRUCTURAL COMPONENTS OF THE DERMIS:
This consists largely of collagen (Type I collagen) and reticulin (Type III collagen), which provide tensile strength. Elastic fibers provide for restoration of shape after a deformation
b. Ground substance
This constantly undergoes synthesis and degradation, and consists largely of glycosaminoglycans: hyaluronic acid, chondroitin sulfate, and dermatan sulfate.
This layer contains adipose tissue made up of fat cells and serves to attach the dermis to its underlying tissues. The fat cells also serve as depocit of nutrients for the body, mostly energy reserves in the form of fat. The fat also is a protective pad for the underlaying body structures against physical impacts. In this layer one also has the greater blood veins and arteries that serve the skin. Also this layer has some fibers that give some rigidity.
D. ADNEXCTAL STRUCTURES (epidermal appendages)
these components are of epidermal origin and extend into the dermis and partly the subdermis too. They include the pilosebaceous unit (hair follicle, sebaceous glands, arrector pili muscle), exocrine sweat glands (and, in some locations, apocrine sweat glands), and nails.
KERATINS - IMPORTANT STRUCTURAL PROTEINS
Keratins are the cytoskeletal components of all cells of epithelial origin, varying in molecular weight depending on the type of epithelia. Keratin is one of the 5 classes of intermediate filaments, each found in a different cell type.
Intermediate filaments (10nm): These serve a distinct cytoskeletal function. Three of the 5 classes of intermediate filaments are found in the skin: Keratin, Vimentin, and Desmin. Keratin is composed of both acidic keratin and basic keratin, which together function to strengthen and stiffen the intercellular junctions and laminate to form protective layers. Vimentin is the major cytoskeletal protein of connective tissue cells, melanocytes and Langerhans cells. Desmin filaments hold myofibrils in place in muscle cells.
Different forms of keratines: The differentiated state of epidermal cells--basal or granular layer-- determines which of the 20 various polypeptides will be produced. There are keratin polypeptides which can be recognized only in the basal cell layer--the low molecular weight (50,000-58,000)-- and others,which are of high molecular weight (57,000-67,000) and appear first in the spinous and granular layers. Other keratin polypeptides are found in all epidermal cells. Several different keratins are made in nails, hair, and stratum corneum.
The aging of the skin
WHAT HAPPENS WHEN THE SKIN IS AGING AND HOW DOES SKIN AGING OF MEN AND WOMEN DIFFER?
The processes of aging differ in male and female skin.
In men, there is a gradual thinning of male skin with increasing age of approximately 1% per year. On the other hand the thickness of most women's skins remains surprisingly constant until the menopause, after which there is a significant and sometimes dramatic thinning with increasing age.
There is a relationship between skin thickness and collagen content in men of all ages. A similar relationship exists among women over 60 years of age, but it is less evident in younger women.
In adult skin, the features of aging are closely related to the total collagen content, which in both sexes decreases with increasing age, but at different rates.
In later life women may look. Older than men of the same age and similar experience of sun exposure, partly because their skin has a lower collagen content to start with. Another reason for the gender difference in skin collagen content may be the difference in male hormone production between men and women.
In women, estrogen and androgen output from the ovaries and adrenal glands falls after menopause, resulting in decreased collagen synthesis and repair.
Aging related to the failure of estrogen production at the menopause accentuates intrinsic aging, and together with photoaging may dramatically increase the apparent age of a menopausal woman.
Estrogen deficiency particularly affects the fibroblasts of the dermis, and thinning of the skin is primarily related to a decrease in the production of collagen. This decrease is relatedto a decline of bone mineral content with age, which can lead to the condition of osteoporosis. The fibroblasts are also responsible for the synthesis of the dermis ground substance, particularly glycoproteins and hyaluronic acid (which is able to bind water). The decrease in fibroblast activity with age accounts for the decreased dermal hydration. Skin elasticity decreases with age, but the effect is more marked in women than in men.
In the epidermis, a lack of estrogen slows down the activity of the basal keratinocytes,and consequently leads to epidermal atrophy. This atrophic fragile skin is less well protected by the normal surface film of lipids, because of the slow decline in sebum secretion experienced by everyone as they age. The stratum corneum barrier is less effective, and the skin may develop reactions to irritants, particularly if skin care has been inadequate or too aggressive.
SUN EXPOSURE AS A MAJOR CAUSE OF SKIN AGING AND POSSIBLE PREVENTION STRATEGIES
The skin is subject to the same aging process as other body tissues. The skin is also directely influenced by additional environmental facors accelerating the aging process, of which sunlight is the most important
Repeated exposure to ultraviolet radiation in sunlight causes skin to age prematurely-a condition called photoaging. Photoaged skin has wrinkles, brown spots, changes in pigmentation and surface roughness. These skin changes are not part of the natural, normal aging process.
The most likely cause for the visible wrinkling associated with photoaging is the breakdown of collagen-the major structural material in skin. Ninety-five percent of the dermis, or underlying layer of skin, is made of collagen.
Ultraviolet radiation in sunlight triggers a molecular chain reaction which produces large amounts of enzymes called matrix metalloproteinases (MMPs). MMPs break apart and degrade collagen. While skin has a natural ability to repair damaged collagen, these repairs are never perfect.
Tiny amounts of at first invisible scar tissue build up over time and eventually become visible as wrinkles (photoaging).
U-M scientists found that MMP levels in dermal skin were directly associated with the length and frequency of exposure to ultraviolet light. Exposure to small amounts of UV (too small to cause skin redness) every other day was enough to induce sustained MMP production at high levels in the individuals in this study.
Pretreating skin with retinoic acid before UV exposure inhibited production of MMPs and resulting collagen damage by 70 to 80 percent in the U-M study. Because it blocks MMP production, retinoic acid should also prevent photoaging, although more research will be needed to know for sure.
The possibility of photoaging prevention is a surprising outcome of this study. Retinoic acid is already approved by the FDA to treat photoaging that has already happened. But until now, the possibility that vitamin A and retinoic acid might prevent photoaging has not been seriously considered.
While retinoic acid blocks MMP production, it has no effect on the skin's ability to produce enzymes called Tissue Inhibitors of MetalloProteinases (TIMPs) which naturally prevent MMP-induced collagen damage. Retinoic acid may prevent photoaging by reducing amounts of harmful enzymes in the dermis, while maintaining normal levels of tissue-protecting proteins (TIMPs).
Future research will attempt to discover how retinoic acid blocks MMP activation when skin is exposed to ultraviolet light. U-M scientists are exploring the role played by a protein called AP-1, which "turns on" genes in skin cells causing them to produce both MMPs and TIMPs.
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These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. This information is nutritional in nature and should not be construed as medical advice. This notice is required by the Federal Food, Drug and Cosmetic Act.